Abstract
Neutralized acidic extracts of rat hypothalamic tissue stimulated release of follicle-stimulating hormone from adult male rat pituitary tissue during a 6-hr incubation period. A graded response was observed in release of FSH by pituitary tissue in response to doses of extract ranging from 1/32 to 1/4 hypothalamic equivalent per incubated pituitary. Evidence was obtained that castration increases and testosterone propionate injections reduce the FSH-releasing activity of hypothalamic extracts. (Endocrinology 78: 500, 1966)
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