Abstract
Abstract Solutions of hypertonic glucose given intravenously to rabbits were found to induce nonketotic, metabolic acidosis with lactic acidemia. Infusions of hypertonic mannitol induced metabolic acidosis but without lactic acidemia. During glucose infusions a rise in lactate and pyruvate concentrations was associated with a derangement of the lactate/pyruvate (L/P) ratio with the formation of "excess lactate" (XL). Analysis of Po 2 and O 2 saturation of arterial blood and determinations of systolic blood pressure revealed that overt hypoxia did not occur during the glucose infusions. Microscopic examination of the capillary bed hemodynamics of the rabbit-ear chamber showed no difference between intravenously infused animals and noninfused controls. Lactate contributed in part to the metabolic acidosis in glucose-infused animals, since the increase of blood lactate accounted for the anion gap and decrement in bicarbonate. Metabolic acidosis from mannitol infusions was due likely to hypertonic injury to cells.
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