Abstract
Objective To investigate the effects of hypertonic- hyperoncotic solution ( HHS) given immediately after cardiopulmonary resuscitation ( CPR) on myocardial and brain injury and gastric mucosal microcirculation. Methods Twenty male rabbits weighing 1.9-2.1 kg were randomly divided into 2 groups ( n = 10 each): control group and HHS group. The animals were anesthetized with chloral hydrate 300 mg/kg iv, tracheotomized, intubated and mechanically ventilated (FiO_2 40% , V_T 10 ml/kg, RR 20 bpm). Femoral artery and vein were connulated for BP monitoring, blood gas analysis and fluid administration. Internal jugular, vein was cannulated for CVP monitoring. ECG was continuously monitored. Gastric intramucosal pH, blood coagulation and serum S-100 and cTnI concentrations were measured before (baseline) and at 30, 60, 120, 180 and 240 min after return of spontaneous circulation (ROSC) . Cardiac arrest was induced by occlusion of tracheal tube and confirmed by ECG (asystole, ventricular fibrillation) and sudden sharp drop in BP. After being suffocated for 10 min, basic life support ( BLS) and advanced cardiac life support (ACLS) were started. Upon ROSC the animals received 4 ml/kg of normal saline (NS) or 7.2% NaCl + 10% hydroxyethyl starch 200/0.5 (HHS) .Results The serum levels of cTnI and S-100 were significantly increased after ROSC as compared with baseline in both groups and were significantly lower in HHS group than in control group. The gastric intramucosal pH was significantly decreased after ROSC in both groups and was significantly higher in HHS group than in control group. Conclusion HHS given immediately after ROSC can ameliorate ischemia-reperfusion injury to heart and brain and improve gastric intramucosal microcirculatory perfusion. Key words: Saline solution; hypertonic; Hetastarch; Cardiopulmonary resuscitation; SI00 proteins; Troponin I; Hydrogen-ion concentration
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
