Abstract
It is known that maternal fever and antenatal infection may lead to abnormal labor. However, the cellular mechanisms by which fever and infection affect labor are poorly understood. Here we investigate the effects of temperature on uterine smooth muscle cell (UtSM) cell calcium regulation as representation of uterine contractility. UtSM were treated with Lipopolysaccharide (LPS), at increasing temperatures (room temperature up to 390C). The aim of our study is to better understand the effects of both temperature and infection on underlying cellular mechanisms of abnormal labor.
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