Abstract
The electrical activity (electroencephalogram, EEG) and oxygen tension of the globus pallidus and neostriatum were studied in anesthetized rats under hyperbaric oxygenation (100% oxygen at 5 atm absolute). An increase in oxygen tension was correlated with an increase in electrical activity in the globus pallidus. The changes in oxygen tension and EEG of the neostriatum did not appear to be significant. Exposure to a hyperoxic environment produced an initial desynchronization of the EEG which was observed in only the globus pallidus. The results of this study suggest a correlation between oxygen tension, electrical activity, and pathological changes observed in selected subcortical nuclei.
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