Effects of hyperbaric oxygen on the level of excitatory amino acids in the brain of rats with brain injury

Abstract

Objective To study the effect of hyperbaric oxygen on the level of excitatory amino acids in the brain of rats with brain injury. Methods By making the models of traumatic brain injury in rats and design randomized experimental group: model control group, high pressure group, high concentration oxygen group and hyperbaric oxygen group were treated with brain injury rats. The contents of glutamic acid (Glu) and aspartate (Asp) were measured in rats at third days, sixth days and ninth days respectively. The contents of glutamic acid (Glu) and aspartate (Asp) were measured in rats at third days, sixth days and ninth days respectively. Results The content of Glu and ASP in the brain tissue of rats with brain injury increased significantly and hyperbaric oxygen can be significantly reduced content of Glu and ASP. Compared with model control group, there were significant differences (P 0.05). Conclusion Hyperbaric oxygen can significantly inhibit the release of excitatory amino acids in brain tissue of rats with traumatic brain injury and reduce the secondary brain damage after traumatic brain injury, while high pressure, high concentration of oxygen can not significantly inhibit the release of EAA. Key words: Cerebral injury; Excitatory amino acids; Hyperbaric oxygen therapy