Effects of hyperbaric oxygen on the contents of serum high sensitivity C-reactive protein and blood glucose in patients with cerebral hemorrhage

Abstract

Objective To study the effects of hyperbaric oxygen (HBO) therapy on the contents of serum high sensitivity C-reactive protein ( hs-CRP ) and blood glucose ( BG ) in patients with intracerebral hemorrhage. Methods One hundred and twelve were selected as subjects, and divided into routine treatment group (57 cases) and HBO treatment group (55 cases), and 50 healthy subjects were chosen as the control.Then, observations were made on the contents of serum hs-CRP and BG in subjects before and after therapy.The therapeutic efficacy was evaluated by scores of neurologic impairment (NIHSS) and activities of daily life (ADL) before treatment and on the 15th and 30th days after treatment. Results The contents of serum hs-CRP and BG in routine and HBO groups were all higher than those of the control group on the day of admission ( P ＜0. 01 ), but there was no statistical difference between the 2 groups. Contonts of serum bs-CRP and BG in both groups decreased significantly after therapy, with the reduction of data being sharper in HBO group and statistical difference could be seen between both groups (P ＜0. 05 ). For the HBO group, contents of serum hs-CRP and BG almost returned to normal after 2 sessions of HBO therapy, and no statistical significance was noted when compared with those of the control group (P ＜ 0. 05 ). There was significant improvement in NIHSS and ADL in the HBO group, when compared with those of the routine group on the 15th and 30th days after treatment ( P ＜ 0. 01 ). Conclusions HBO treatment can effectively reduce the contents of serum hs-CRP and BG in patients with intracerebral hemorrhage, improve neurologic impairment and activities of patients' daily life. Key words: Hyperbaric oxygen; Intracerebral hemorrhage; High sensitivity C-reactive protein; Blood glucose