Abstract
Abstract The effects of hydroxypropylmethylcellulose (HPMC) moisture content on the properties of tablets made with HPMC as base excipient were investigated. Two varieties of HPMC, with nominal viscosities of 4000 and 100 000 cP, were evaluated. The drug model used was hydrochlorothiazide, present in tablets at 1% w/w. The results for both HPMC varieties indicate that variation in HPMC moisture content over the range 2.25–10.85% has no significant effects on drug release profile, despite the fact that HPMC moisture content is positively correlated with the tensile strength of tablets.
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