Effects of hyaluronic acid on bone graft healing: An experimental study on sheep

Abstract

Background and objectives: Alloplastic is one of known materials have been used to treat bony defects in oral and maxillofacial region, but the healing is much more slower than auto graft . So many interpositional graft materials like hyaluronic acid and bone morphogenetic protein have been introduced to such material to induce osteoinductivity of graft material. The aim was to evaluate the histological effect of Hyaluronic acid on bone graft substitute. Materials and methods: An experimental study carried out on 3 domestic sheep 2-4 years old. They divided into two groups, first group (study group): bone graft substitute mixed with hyaluronic acid introduced to the created cavities in the basal bone of mandible. Second group (control group): bone graft substitute were introduced into created cavities in the basal bone of mandible and the defects in both groups were covered with collagen membrane. The samples then sacrificed in deferent period interval 2 weeks, 6 weeks and 12 weeks and the sample collected and sent for histological examination. Results: All animals survived till the end of study. Both groups were characterized by new bone formation in defects however the bone formation in group 1 significantly preceded. Conclusions: Hyaluronic acid induces the onset of new bone formation when mixed with alloplastic material. Conclusions: Hyaluronic acid induces the onset of new bone formation when mixed with alloplastic material.