Abstract
In this study, effects of hot water extract of Paecilomyces hepiali mycelia on hypertension parameters in spontaneously hypertensive rats (SHR) were investigated. The tested parameters included blood pressure, blood and urine biochemical composition, renin and angiotensin II levels in the blood. Prior to these tests, the extract was examined for toxicity. The fungus was cultivated in a solid medium composed of 40 g brown rice, 0.32 g glucose, 0.65 g sucrose, 2 g peptone and 65 ml corn steep liquor. No abnormality or harmful effects were observed in the toxicity test. Administration of a continuous-dose, once daily, to SHR for 27 weeks (from 13 weeks of age) decreased the systolic blood pressure (SBP) significantly. Levels of blood urea nitrogen, β-lipoprotein lipid peroxides and low density lipoprotein were significantly lower in the treated groups when compared to the control group. Urinary protein was significantly reduced in the middle and high dose groups. In comparison with the control group (0 mg/kg/10ml/day), significantly higher values were obtained for total cholesterol in groups that were given middle (170 mg/kg/10ml/day) and high (250 mg/kg/10ml/day) dosages. In all dosages (low, middle and high) the values for triglyceride were significantly higher than value found in the control group. In terms of angiotensin II levels, the value in the control group was markedly higher than values in the other groups. The results suggest that oral administration of hot water extract of P. hepiali mycelia has ability to control hypertension in rats.
Highlights
A number of fungi have been described as anamorphs of Ophiocordyceps sinensis
These include Stachybotrys sp., Paecilomyces sinensis, Scytalidium hepiali, Tolypocladium sinensis, Chrysosporium sinensis, Hirsutella sinensis, Synnematium sinensis, Cephalosporium sp., Paecilomyces hepiali, Mortierella hepiali, and Scytalidium hepiali [2]. These species have been used for mass production of mycelia for making various commercial products labelled as O. sinensis or C. sinensis
Chen et al [2] describes the labelling of mycelia products from all these isolates as O. sinensis or C. sinensis to be confusing to the consumer because at the moment it is only H. sinensis and not the other isolates which have been confirmed as the correct anamorph of O. sinensis [3]-[5]
Summary
A number of fungi have been described as anamorphs of Ophiocordyceps sinensis (former name: Cordyceps sinensis). Since the 1980s 22 species in 13 genera have been attributed to the anamorph of O. sinensis [1] These include Stachybotrys sp., Paecilomyces sinensis, Scytalidium hepiali, Tolypocladium sinensis, Chrysosporium sinensis, Hirsutella sinensis, Synnematium sinensis, Cephalosporium sp., Paecilomyces hepiali, Mortierella hepiali, and Scytalidium hepiali [2]. These species have been used for mass production of mycelia for making various commercial products labelled as O. sinensis or C. sinensis. Effects of hot water extract of P. hepiali mycelia on hypertension related parameters in spontaneously hypertensive rats (SHR) were investigated. Prior to the aforementioned studies, the hot water extract of the fungus was evaluated for toxicity using ICR rats
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