Abstract
This review will clarify the complex relationship of hormonal contraception and mood in women both with and without mood disorders, in adolescents, and in postpartum women. Though the overall effect of hormonal contraception on mood does not appear to have a significant clinical impact, several recent population-based studies suggest adolescents are potentially more vulnerable than adults. Strategic initiation of hormonal contraception may mitigate mood symptoms, with continuous regimens of hormonal therapy demonstrating some benefit over cyclic regimens. Additional rigorous studies are needed to measure the impact of hormonal contraception on mood relative to dose and formulation, particularly in those women with pre-existing mood disorders.
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