Abstract
Hopeaphenol and malibatol A isolated from the bark of Hopea odorata Roxb were found to have a multitarget effect for the dental caries pathogen Streptococcus mutans. Hopeaphenol and malibatol A at a concentration of 4 mM inhibited acid production by Streptococcus mutans GS-5 in a pH-drop assay with excess glucose. Both the compounds at milimolar concentrations were also found to be highly lethal for S. mutans GS-5 and their lethal effect at pH 4 was stronger than that at pH 7. Our further studies indicated that hopeaphenol and malibatol A in the same range of concentrations inhibited the activity of membrane enzymes (F-ATPase, phosphoenol pyruvate: phosphotransferase system), glycolyic enzymes (pyruvate kinase, lactate dehydrogenase) and NADH oxidase of S. mutans. The obtained results suggested that the two compounds could have a potential use in oral care products.
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