Abstract
Introduction: Honey is not just a sweetener it is also a nature’s gift to mankind. Natural honey has various ingredients in it that contribute to its incredible properties. Honey contain health-beneficial effects such as gastro protective, hepatoprotective, reproductive, hypoglycemic, antioxidant, antibacterial, and anti-inflammatory effects. For that reason, honey could be considered as a potential remedy for diabetes as well as Cardiovascular Disease(CVD). The objective of this study was to determine the phytochemical activity of honey and its role on hypoglycemic and hypolipidemic condition in Streptozotocin- induced diabetic rats. Material and method: The Experimental rats were divided into six groups (n=6). Diabetes Mellitus (DM) was induced by single intraperitoneal injection (65 mg/kg BW) of freshly prepared Streptozotocin hydrate solution in 0.9% saline solution. Hyperlipidemic was induced by mixture of cholesterol (1.5 %) and cholic acid (0.5%) with diet of rats. At the end of the treatment, the blood glucose level and lipid profile was measured by using commercial kits. Result: Honey bee-treatment significantly decreases blood glucose level in diabetic rats. TC, TG, LDL, VLDL are significantly (p<0.05) decrease whereas HDL significantly increase (p<0.001). The SGPT, SGOT and CRP were significantly decrease (p<0.05). The total phenolic and flavonoid were determined by Folin-Ciocalteu and colorimetric assay method where some flavonoid decreases diabetic condition as well as CVD. Honey has also effect of hepatoprotective activity. Conclusion: On the basis of above findings, it can be concluded that, supplementation of honey could significantly contribute to control blood glucose level as well as lipid profile in diabetic subjects.
Highlights
Honey is not just a sweetener it is a nature’s gift to mankind
Another serious pathogenesis of diabetes is an abnormal lipid profile indicated by low levels of High density lipoprotein (HDL) and high concentration of triglyceride and Low density lipoprotein (LDL)
In the last few years, there has been an increased interest in the therapeutic uses of honey. This is largely due to an increase in the availability of evidence-based findings demonstrating the health beneficial effects of honey in treating diverse disease conditions including diabetes mellitus and cardiovascular disease (CVD)
Summary
Honey is not just a sweetener it is a nature’s gift to mankind. Natural honey has various ingredients in it that contribute to its incredible properties. As a result of these limitations and unmet goals, a large percentage of the population is resorting to CAM [4] This alternative approach to diabetes therapy includes the use of herbal preparations, dietary components or supplements and other natural products such as honey [5]. In the last few years, there has been an increased interest in the therapeutic uses of honey This is largely due to an increase in the availability of evidence-based findings demonstrating the health beneficial effects of honey in treating diverse disease conditions including diabetes mellitus and cardiovascular disease (CVD). Major component of honey are melittin and phospholipase A2, a polypeptide and an enzyme that increase insulin secretion from pancreatic β-cells via depolarization of beta cell membrane [6] Another potential mechanism is lowering blood glucose and cholesterol reducing action is lipolytic properties of Honey.
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