Abstract
Levels of cyclic adenosime monophosphate (cAMP) in lymphocytes are regulated by β-adrenergic agonists and PGE 1. The effect of these agonists is potentiated by cortisol. Incubation of lymphocytes with histamine-sensitizing factor (HSF) leads to loss of response to epinephrine and PGE 1. The response can be partially restored by cortisol. Incubation of lymphocytes with β-adrenergic antagonists such as propranolol leads to the loss of β-adrenergic agents but not PGE 1 The inhibition by propranolol is not reversed by cortisol. These results suggest that the action of HSF and Bordetella pertussis vaccine is not mediated through the inhibition of β-adrenergic receptors alone.
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