Effects of high intensity training on glycated hemoglobin type A1C reduction and insulin resistance changes compared to moderate intensity training in patients with type 2 diabetes : a systematic review and meta analysis

Abstract

Background: In most of the type 2 Diabetes management recommends lifestyle including physical activity. Several studies have examined the effects of HIT and MIT on the glycated Hemoglobin type A1C (HbA1c) and Insulin resistance reduction in type 2 Diabetes. Objective: The objective of this meta-analysis was to investigate the impacts of high and moderate intensity training to reducing HbA1C and changes insulin resistance in type 2 Diabetes Melitus patient.State the objectives of the research. Material and Method: We searched the online databases of PubMed, ScienceDirect, and Cochrane Library for relevant studies evaluating the effects of High Intensity Training on T2DM patients. Using random effects model, comparing Mean Difference and standard deviation with 95% confidence internal (CI) were used to investigate the studies.Conclusion: In this study we found that HIT showed significantly better result to reduced HbA1C. HIT improves glucose control center’s ability to recruit more muscle fibers and depleting muscle glycogen levels compared to MIT, HIT does not significantly reduce insulin resistance compared to MIT.