Abstract
Objective This study was designed to probe into the changes and clinical significance of GRP78 and miR-495-3p in renal failure (RF) patients during high-flux dialysis (HFD) combined with hemoperfusion (HP). Methods Sixty-five RF patients and 74 health check-ups who were admitted in our hospital from March 2015 to February 2017 were prospectively selected, and the related characteristics were retrospectively collected for analysis. GRP78 and miR-495-3p were detected in RF patients at admission (before treatment), 12 weeks after treatment (during treatment), 24 weeks after treatment (after treatment), and the control group at admission, and the relationship between the two and the occurrence, efficacy, and recurrence of RF was analyzed. Results Before treatment, the GRP78 mRNA level in RF patients was higher than that in health check-ups, while the miR-495-3p level was lower (P < 0.05). GRP78 mRNA in RF patients was lower than that before treatment and was the lowest after treatment. On the contrary, miR-495-3p was higher than that before treatment and was the highest after treatment (P < 0.05). The two had a significant effect on predicting RF before treatment, efficacy of patients, and their recurrence after treatment (all P < 0.001). Conclusion GRP78 decreased during the treatment of high-flux hemodialysis (HF-HD) combined with systemic HP in RF patients, while miR-495-3p increased. Both of them have a good reference value for RF occurrence, treatment results, and recurrence.
Highlights
Renal failure (RF) is a pathological state in which all kinds of chronic kidney diseases develop to the later stage and cause partial or total loss of renal function, and it is very common clinically [1]
ROC curve analysis manifested that when glucose-regulated protein 78 (GRP78) mRNA > 2:395 before treatment, the sensitivity and specificity of predicting RF were 58.46% and 97.30% (P < 0:001)
The treatment of RF patients is the top priority in clinical research, and the effect of high-flux hemodialysis (HF-HD) combined with systemic HP on RF has been preliminarily determined [19, 20]
Summary
Renal failure (RF) is a pathological state in which all kinds of chronic kidney diseases develop to the later stage and cause partial or total loss of renal function, and it is very common clinically [1]. The morbidity of RF is high among middle-aged and elderly people, and the main reason may be related to body function decrease of patients [2]. Stage of RF is characterized by oliguria, anemia, etc., which is ignored by patients [5]. It is not difficult to cure early RF, and most patients can achieve a more rational state by controlling the etiology and diet [6]. Once the disease develops to the middle and late stage, it may only be treated by kidney transplantation [7]. We always attach great importance to RF in clinical practice and constantly explored new and effective diagnosis and treatment methods [1, 8]
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