Abstract
To evaluate the effects of hemodialysis (HD) on corneal and anterior chamber morphometry, as well as intraocular pressure (IOP) in patients with end-stage renal disease. Fifty right eyes were examined 30 minutes before and after HD. IOP was measured with a Goldmann applanation tonometer, and Ehlers' formula was used to calculate the corrected IOP values. The central corneal thickness (CCT), corneal volume (CV), keratometric values, anterior chamber depth (ACD), aqueous depth (AQD), anterior chamber volume (ACV), and anterior chamber angle (ACA) in the nasal and temporal quadrants were measured with a Sirius anterior segment analysis system. Blood urea nitrogen levels, body mass, and systolic and diastolic arterial pressure were also measured before and after HD. The mean age was 60.80 ± 13.38 (range: 35-80) years. The mean uncorrected and corrected IOP values decreased from 18.06 ± 3.91 and 18.31 ± 4.83 mmHg to 16.94 ± 3.87 and 16.95 ± 4.74 mmHg after HD, respectively (p=0.011 and p=0.003, respectively). The mean CCT decreased from 536.38 ± 24.73 to 533.18 ± 27.25 µm (p=0.002), and the mean CV decreased from 57.52 ± 3.15 to 55.68 ± 3.55 mm³ (p<0.001) after HD. There were no significant changes in ACD, AQD, ACV, ACA, or the keratometric values (p>0.05 for all values). There were no significant correlations between the ocular and systemic parameters (p>0.05 for all correlations). Uncorrected IOP, corrected IOP, CCT, and CV values decreased after HD, whereas the anterior chamber morphometry values remained similar between the measurements performed before and after HD.
Highlights
Hemodialysis (HD) is the main treatment for end-stage renal di sease (ESRD)
Acute and chronic complications can occur after HD, the most common of which are hypovolemia and sudden changes in hemodynamic parameters, which may cause organ dysfunctions[1]
There are many ocular disorders associated with HD, including refractive changes, dry eye, corneal and conjunctival epithelial erosions, perilimbal calcium deposits, band keratopathy, intraocular pressure (IOP) fluctuations, posterior subcapsular cataract, ischemic optic neuropathy, choroidal perfusion delay, corneal endothelium alterations, and thickness changes in the central cornea, retinal nerve fiber layer, and choroid[2,3,4,5,6,7,8,9,10,11,12,13,14,15]
Summary
Hemodialysis (HD) is the main treatment for end-stage renal di sease (ESRD). acute and chronic complications can occur after HD, the most common of which are hypovolemia and sudden changes in hemodynamic parameters, which may cause organ dysfunctions[1]. Fluid dynamic changes after HD can affect ocular tissues that receive a high volume of blood flow. There are many ocular disorders associated with HD, including refractive changes, dry eye, corneal and conjunctival epithelial erosions, perilimbal calcium deposits, band keratopathy, intraocular pressure (IOP) fluctuations, posterior subcapsular cataract, ischemic optic neuropathy, choroidal perfusion delay, corneal endothelium alterations, and thickness changes in the central cornea, retinal nerve fiber layer, and choroid[2,3,4,5,6,7,8,9,10,11,12,13,14,15]. Among the various studies investigating the relationships between ocular alterations and HD, IOP is the most commonly investigated parameter, and conflicting results have been reported[16].
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