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Abstract
Application of harmine (10 mg/kg IP) 30 min before apomorphine decreased the motoric effects of the latter. Following harmine an increase in 5-HT and a decrease in 5-HIAA in different brain regions have been found. Injection of 5,6-DHT into nucleus medians raphe 7 days before the experiment caused a significant increase of the apomorphine effect. Harmine pretreatment reduced this excessive motility as well additional lesion of the substantia nigra with 6-OH-DA. Lesion induced by 76-OH-DA alone was without significant effect on the hypermotility following apomorphine. Application of PCPA 3 days before testing elicited an increase of apomorphine-induced hypermotolity which could be abolished by preceding harmine application. The experiments demonstrate the inhibitory effect of the central serotoninergic system on the apomorphine syndrom as well as the serotoninergic-dopaminergic interaction in hypermotility.
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