Abstract
The effects of halothane on deoxyribonucleic acid (DNA) synthesis and events preceding DNA synthesis have been examined in Chinese hamster fibroblasts in culture.DNA synthesis was studied by the uptake of 3H-thymidine during short periods of incubation that minimized effects on cells in the presynthetic phase (G1). Halothane produced slight but significant dose-related depression of 3H-thymidine uptake (20 per cent depression with 2 per cent halothane). In a separate series of experiments, synchronized cultures were exposed to 1-3 per cent halothane in G 1 phase for three or five hours. Halothane caused a postponement of onset of DNA synthesis (S phase), indicating a delay in G 1. This delay roughly equalled the duration of exposure to 3 per cent halothane but was less with 2 per cent halothane. The delay was only about one hour with 1 per cent halothane.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
