Abstract
A study was undertaken to investigate the effects of halothane anaesthesia alone on carbohydrate and fat metabolism in twenty male surgical patients by determining plasma growth hormone (HGH), insulin, glucose and free fatty acids (FFA), and to compare these with the effects of anaesthesia plus surgery. The plasma HGH level during halothane anaesthesia alone for 45 minutes was slightly increased, and rose significantly during operation and in the postoperative period. The peak level was achieved 30 minutes after the start of surgery. Plasma insulin levels did not change appreciably during anaesthesia alone or during surgery. Blood glucose levels increased slightly during anaesthesia alone, and rose significantly during operation and in the postoperative period. The plasma FFA level did not change during halothane anaesthesia alone, but rose slightly (but insignificantly) during operation and in the postoperative period. The clinical significance of the results is discussed.
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