Abstract
The growth of neocortical pyramidal cell dendrites and the number of ethanolic-phosphotungstic acid-stained synapses in the rat brain was studied at various times following survival from experimentally produced neonatal Haemophilus influenzae meningitis with bacteremia. The mean number of dendrites and the branching complexity of 30 neurons in rats 7, 20, 40 and 67 days of age following intranasal inoculation of bacteria on day 5 was less than age-matched controls. The mean number of synapses was reduced in three postmeningitic and three control rats at 40 and 67 days of age. This data suggests that reduced neuronal connectivity resulting from neonatal meningitis with bacteremia may be an anatomic correlate of the postmeningitic learning disorders.
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