Abstract
The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abnormal metaphases. The clastogenicity of curcumin may be related to its pro-oxidant properties and its ability to generate free radicals.
Highlights
The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells
Curcumin reduces chromosomal aberrations in rodent bone marrow cells exposed to gamma-radiation or treated with the antitumor drug cisplatin (Abraham et al, 1993; Antunes et al, 2000)
An increase in the frequency of chromosomal damage has been seen in mice and rats treated acutely and chronically with curcumin (Giri et al, 1990; Mukhopadhyay et al, 1998), and curcumin is mutagenic in cultured Chinese hamster fibroblasts (Ishidate et al, 1984)
Summary
The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Mutagenic in cultured CHO cells and, when combined with the antitumor drugs bleomycin or doxorubicin, the frequency of chromosomal aberrations is markedly increased (Araújo et al, 1999; Antunes et al, 1999). In agreement with this proposed mechanism, thiourea, a hydroxyl radical scavenger, significantly inhibited the increase in chromosomal aberrations in CHO cells treated with curcumin (Araújo et al, 2001).
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