Effects of guanidino compounds on the electrical activity of giant neurons identified in subesophageal ganglia of the African giant snail, Achatina fulica Ferussac

Abstract

1. The effect of 20 guanidino compounds was examined individually on the electrical activity of two spontaneously firing giant neurons [periodically oscillating neuron (PON) and tonically autoactive neuron (TAN)] identified in the subesophageal ganglia of the African giant snail, Achatina fulica Férussac. 2. Guanidinoacetic acid (GAA) at high concentration (10 −4 g/ml) was the only examined compound that showed an inhibitory effect on TAN. No guanidino compound examined had an effect on the PON excitability.