Effects of growth inhibitors on response of rat's uterus to estrogen.

Abstract

SummaryAminopterin, beryllium, cadmium, and strychnine proved effective in reducing the physiological activity of estradiol. All compounds except strychnine effected a decrease in total nitrogen content in the uteri of ovariectomized rats receiving estradiol. Such inhibition was associated with a decrease of water in the uterine tissue and the absence of fat and glycogen. Thus, the inhibitory process is associated with these physiological changes.