Abstract
Results: Liver cirrhosis was indicated by high plasma ALT, direct bilirubin level, tissue MDA, and low SOD. The antioxidant enzymes SOD and CAT were low (P < 0.01) in cirrhotic and green tea-treated rats. High activity (P < 0.01) of ALT was observed in green teatreated cirrhotic rats. The total and direct bilirubin levels were high (P < 0.01) in CCl 4 -treated cirrhotic rats while they were low (P < 0.05) in green tea-treated cirrhotic rats. The tissue MDA was high (P < 0.01) in CCl 4 - and green tea-treated cirrhotic rats. ACE gene expression after 8 weeks of CCl 4 treatment in cirrhotic rats was significantly high (P < 0.05), and was reversed in green tea-treated cirrhotic rats in comparison to controls. Conclusion: The administration of green tea tries to correct the deteriorative biochemical and genetic changes during CCl 4 -induced liver cirrhosis in rats. The long-term consumption of green tea has beneficial effects on abnormally increased ACE gene activity during liver cirrhosis caused by CCl 4 administration in rats.
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