Abstract
Male mice were subcutaneously injected with several gonadal hormones daily for 5 days in order to study their effects on hyaluronic acid (HA) content in the skin.Increases in both total hexosamine and HA contents were in the following order: estradiol-17β(10μg)> estradiol-17α(10μg)> estradiol-17α(10μg)> testosterone (100μg)>control (p<0.001). NO Significant differences were noted between 5α-dinydrotestosterone (100μg) and control. Testosterone (100μg) or 5α-dihydrotestosterone (100μg) injected with estradiol-17β(10μg) blocked the increase in HA content produced by estradiol-17β alone.Thus, it can be suggested that an increase in HA is not specific for estradiol-17β and that the action of testosterone or 5α-dihydrotestosterone is antagonistic to that of estradiol-17β in the male mouse skin.
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