Abstract
SUMMARY The objective of this study was to evaluate the effects of glutamine supplementation on performance and intestinal immune parameters of broilers during an experimental coccidiosis infection. There were 3 glutamine supplementation levels in this study: 0, 0.5, and 1.0%. At 14 d of age, each bird was given an oral gavage of 20X dose of Coccivac B52 suspended in distilled water. IFN-γ mRNA levels were downregulated 11.8- and 2.0-fold in the jejunum and 8.1- and 7.9-fold in the cecal tonsils of birds supplemented with 0.5 and 1.0% glutamine at 21 d, respectively, compared to that in the birds fed 0% supplemental glutamine (P = 0.06 and P = 0.01, respectively). At 21 d of age, IL-10 mRNA levels were downregulated in the jejunum of the birds supplemented with 0.5 and 1.0% having a 25.3- and a 1.5-fold lower level, respectively (P 0.05) were observed on any performance parameter or T-cell population percentages. This study shows that glutamine supplementation upregulated tight junction protein gene expression, improved intestinal morphology, and downregulated pro- and anti-inflammatory cytokine gene expression. In conclusion, these results indicate that dietary glutamine supplementation can improve intestinal health in birds challenged with an experimental coccidiosis infection.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
