Abstract
The experiment was conducted to investigate the effects of diets supplemented with glucose oxidase (GOD) on growth performance, serum parameters and faecal microflora of piglets. One hundred and twelve piglets (35 days old) were randomly assigned to two groups (four replicates per group, half male and half female, and 14 piglets per replicate) and fed a diet with or without 100 U GOD per kg, for 35 days. Feeding GOD caused a higher average daily weight gain and feed intake, and lower feed conversion ratio (FCR) of piglets. No significant difference was observed in the reference values of serum biochemical parameters between the groups fed with or without GOD. The contents of triiodothyronine, thyroxine and growth hormone of piglets fed GOD were higher than those of the control. Moreover, GOD supplementation suppressed the concentration of faecal Salmonella . The results showed that supplementation of GOD to diets promoted growth performance, increased the contents of growth and development-related hormones, and improved the faecal microflora of growing piglets. Keywords: Glucose oxidase, intestinal health, performance, swine
Highlights
Glucose oxidase (GOD) is a flavoprotein, which catalyses the oxidation of β-D-glucose to D-glucono-δlactone and hydrogen peroxide (H2O2), using molecular oxygen as an electron acceptor (Hatzinikolaou et al, 1996; Pluschkell et al, 1996)
Piglets on control and treatment groups were similar in average daily feed intake (ADFI) (P >0.05), but showed significant differences in the final weight, average daily gain (ADG) and feed conversion ratio (FCR) (P
Two products of glucose oxidase (GOD) hydrolysis are H2O2 and gluconic acid, which may act as a bacteriocide (Crueger & Crueger, 1990; Rasiah et al, 2005; Costa et al, 2013) and acidity regulator (Nakao et al, 1997; Klein et al, 2002) to reduce the gastric pH, inhibit harmful bacteria and promote the growth of beneficial bacteria
Summary
Glucose oxidase (GOD) is a flavoprotein, which catalyses the oxidation of β-D-glucose to D-glucono-δlactone and hydrogen peroxide (H2O2), using molecular oxygen as an electron acceptor (Hatzinikolaou et al, 1996; Pluschkell et al, 1996). There are broad prospects for GOD application in the feed industry. Owing to low fermentation capacity and high cost, the application of GOD is limited as a feed additive. The Laboratory for Food Technology developed a new recombinant GOD with high yield (615 U/mL and 2.5 g protein/L in a 3 L fermenter) and favourable properties (Gao et al, 2012)
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