Abstract
The effects of glucose on Ca2+ATPase activity of erythrocyte membranes were investigated under in vitro and in vivo conditions. Results of the study, in vitro, showed that Ca2+ATPase activity of erythrocyte membrane was decreased by increasing glucose concentrations (0-30 mM). When glucose-6-phosphate (0-100 mM) was used instead of glucose no significant change occurred in Ca2+ATPase activity. Tunicamycin (0.01 ng/ml) when added to the incubation media together with glucose prevented the decrease in Ca2+ATPase activity. The results of the studies in vivo showed that Ca2+ATPase activities of both male and female subjects with normal or impaired glucose tolerance were changed with time in a complex manner after an oral glucose loading. However, Ca2+ATPase activities of the subjects with impaired glucose tolerance were smaller than those of the corresponding normal controls even before glucose administration.
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