Abstract

Multi-unit and EEG activity was recorded from discrete hypothalamic loci in anesthetized cats during intravenous injection or infusion of glucose solutions. Glucose diminished multi-unit activity on the lateral hypothalamus and increased activity in the ventromedial hypothalamus. The temporal course of the effects differed in both structures. Similar changes in multi-unit activity were noted in other hypothalamic regions. The EEG effects were found to be generally unreliable or inconsistent. The results support the concept that blood glucose is at least one factor in food intake regulation and further indicate that several hypothalamic regions may be involved in the regulation process.

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