Abstract
Histamine and polyamines in oxyntic mucosa seem to be associated with the pathogenesis of gastric ulcer and with its recovery. In the present study, the effect of dexamethasone and other glucocorticoids on the metabolism of histamine and polyamines was examined in fasted rats. The activity of histidine decarboxylase in rat oxyntic mucosa increased significantly after dexamethasone was injected s.c. to rats at doses larger than 0.4 mg per kg body weight. The maximum response of the HDC activity to dexamethasone (4 mg/kg) was observed at 8 hr after the treatment. The activity of ornithine decarboxylase increased at 4 hr and remained elevated for 16 hr following single injection of dexamethasone. Serum gastrin levels showed no significant increase for the first 4 hr and then rose significantly at 8 and 16 hr after dexamethasone treatment. Betamethasone was nearly as potent as dexamethasone in inducing the activity of decarboxylases, while neither prednisolone nor triamcinolone showed any significant effect. These data suggest that dexamethasone influences the metabolism of histamine and polyamines in rat oxyntic mucosa both directly and via increased gastrin release.
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