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Abstract
Fluoroacetate has been widely used to inhibit glia metabolism in vivo. It has yet to be shown what the effects of chronic intrathecal infusion of fluoroacetate on nociceptive behavioral testing are. The effects of chronic infusion of fluoroacetate (5 nmoles/h) for 2 weeks were examined in normal rats. Chronic intrathecal fluoroacetate did not alter mechanical threshold (von Frey filaments), responses to supra-threshold mechanical stimuli (von Frey filaments), responses to hot (hot plate) or cool (acetone test) stimuli and did not affect motor performance of the animals, which was tested with rotarod. This suggests that fluoroacetate at appropriate dose did not suppress neuronal activity in the spinal cord.
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Chronic intrathecal fluoroacetate did not alter mechanical threshold, responses to suprathreshold mechanical stimuli, responses to hot or cool stimuli and did not affect motor performance of the animals, which was tested with rotarod
Figure Behavioral testing Analyzed Adult rats were intrathecally infused with fluoroacetate for 2 weeks Behavioral testing of nociceptive stimuli Bordeaux, France Data is supplied in the article
Summary
Adult rats (150–175 g) were obtained from Janvier (France) and maintained in a controlled environment (lights on 07:00–19:00, 22 °C) with food and water freely available. All efforts were made to minimize the number of animals used. The experiments followed the ethical guidelines of the International Association for the Study of Pain and the European Community Council directive of 22 September 2010 (2010/63/EU). The project was approved by Bordeaux Ethical Committee (CEEA50) under No 50120169-A. Rats were acclimatized for 4 days to the animal facility and for 5 days to manipulations and devices prior to behavioral studies
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