Abstract
Crude synaptic membrane fractions from the frontal cortex, striatum, brain stem and whole brain of rat were prepared to assay the effects of ginseng total saponin (GTS) on [³H]DAGO bindings of the opioid μ-receptors. Scatchard plots analysis binding data demonstrated that GTS (0.1 mg/ml) decreased the affinity of specific [³H]DAGO bindings without changes in Bmax in the frontal cortex and striatum. On the other hand, GTS did not affect the [³H]DAGO bindings in the brain stem and whole brain. These results suggest that the regulation of [³H]DAGO bindings by GTS may play roles in the change of the pharmacological responses of μ-opioids.
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