Effects of genotype and maternal alcohol consumption on some biochemical parameters of red blood cells in the progeny of mice.

Abstract

Effects of genotype and ethanol consumption by pregnant mothers on hemoglobin (Hb) and red-cell levels of adenosine triphosphate (ATP), 2,3-diphosphoglycerate (DPG), and glutathione (GSH) of their progeny were studied in mice. Three lines of mice were used, one selected for high body weight, another selected for low body weight, and an unselected control. An ethanol solution [10% (v/v)] was given ad lib to the females at the time of joining them with males and continued through the pregnancy. Another group received distilled water for drinking throughout. Blood samples from the progeny of both these groups were taken at 10 weeks of age and analyzed for Hb, ATP, DPG, and GSH levels. Alcohol drinking during pregnancy resulted in lower levels of DPG in the red blood cells of progeny of the lines selected for high and low body weight and the reverse in the unselected line. Maternal alcohol consumption had no effect on Hb, APT, and GSH levels in the red blood cells of the progeny of any of the three lines. Females of both selected lines had higher levels of DPG than males. Artificial selection for body weight resulted in a positively correlated response in the level of red-cell DPG and GSH in the progeny.