Effects of genetic polymorphism of uncoupling protein 2 on body fat and calorie restriction-induced changes1

Abstract

The purpose of this study is to estimate the effects of Ala55Val genetic polymorphism of uncoupling protein 2 on computed tomography-measured body fat area and calorie restriction-induced changes. Among 386 Korean female subjects, the AlaAla type was seen in 30.3%, the AlaVal type was seen in 47.2%, and the ValVal type was seen in 22.5%. This finding was in agreement with Hardy-Weinberg equilibrium. The frequency of the major Ala allele was 0.54, and that of the minor Val allele was 0.46, which were similar to those seen in Caucasian populations. When cross-sectional areas of fat tissues in the subjects were measured by computed tomography, it was shown that the total abdominal fat area and abdominal subcutaneous fat area were significantly smaller in the ValVal type compared with the AlaVal or AlaAla type (p=0.043 and p=0.044, respectively). The Ala55Val polymorphism had no effects on visceral fat area and thigh subcutaneous fat area. Among the 386 subjects, 236 subjects finished the 1-month calorie restriction program. The results showed that the body fat was reduced significantly less in the ValVal type compared with the other types (p=0.016), whereas the changes in lean body mass, protein, mineral, and water contents were not significantly different according to the Ala55Val polymorphism.