Abstract
The effects of γ-aminobutyric acid (GABA) and γ-amino-β-hydroxy butyric acid (GABOB) on the avoidance conditioned reflexes (CR) in dogs were investigated. The results obtained as follows:1. A prolongation of latency and decrement of percentage frequency of CR were observed during the course of acute extinction and discrimination.2. Similar changes of latency and percentage frequency were observed following intravenous and intracisternal administration of GABA or GABOB. There was no marked difference between effective doses of GABA and GABOB.3. The positive conditioned reflexes of discrimination were inhibited following the intravenous administration of GABGB.4. The abnormal behavior observed in the experimental situation (experimental neurosis) disappeared, though temporarily, following the intracisternal administration of GABOB.I wish to thank Prof. K. Motokawa for his invaluable discussion and suggestions throughout the course of the experiment and the preparation of the manuscript.
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