Abstract
Galanin decreased short circuit current ( I sc) and increased Galanin decreased short circuit current ( I sc) and increased active Na + and Cl − absorption in rabbit ileum. In the absence of calcium, the galanin-induced decrease in I sc was inhibited by approximately 60%. Tetrodotoxin significantly reduced the effect of galanin on I sc, and tetrodotoxin and EGTA totally blocked the effect, indicating that the nonneuronal mediator of the effect is Ca 2+ dependent. Galanin binding to basolateral membranes prepared from ileal epithelial cells was specific and of high affinity. These results suggest the involvement of this peptide in the regulation of intestinal epithelial cell function.
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