Abstract
The coexistence of galanin (GAL) with some classical neurotransmitters suggests that it may exert a role as a neuroendocrine modulator. The aim of this study was to investigate the GH response to porcine galanin (p-GAL) in prepubertal male lambs. In the experiments A and B the i.v. infusion of galanin (5 μg/kg) for 60 min was carried out alone (Experiment A) or combined with an i.m. injection of GHRH (0.5 μg/kg) 30 min after infusion (Experiment B); in the Experiment C, galanin (5 μg/kg) was infused for 300 min. Galanin infusion was not effective in increasing GH baseline levels ( P > 0.08); however galanin potentiated ( P < 0.01) the GH responsiveness to GHRH. The prolonged galanin infusion caused a significant increase in GH plasma levels and pulse frequency. These observations support the hypothesis that galanin may be involved in the regulation of somatotropic axis in young animals by modulating both stimulatory and inhibitory hypothalamic factors.
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