Abstract
The effects of GABA agonists on [ 3H] flunitrazepam binding were examined in membranes from CNS areas proposed to contain different populations of benzodiazepine binding site subtypes ( BZ 1 BZ 2 ). Since these effects were broadly similar in both cerebellar and hippocampal membranes, it seems unlikely that GABA receptors interacting with the proposed BZ 1 BZ 2 binding sites haue markedly different properties. Sodium chloride clearly facilitated the potentiating effect of muscimol on [ 3H] flunitrazepam binding but produced a complex interaction uith the effects of GABA itself and the partial agonist imidazoleacetic acid in the phosphate buffer system used.
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