Abstract
BackgroundWhether follicle-stimulating hormone receptor (FSHR) polymorphisms are implicated in premature ovarian insufficiency (POI) remains controversial. Thus, we performed this study to explore correlation between FSHR polymorphisms and POI in human beings.MethodsLiterature retrieve was conducted in PubMed, Medline, Embase and CNKI. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsSixteen studies were enrolled for analyses. No significant relationship with POI was found for rs6165 and rs6166 polymorphisms in overall analyses. Further subgroup analyses revealed that rs6166 polymorphism was significantly associated with the risk of POI in Asians with both FEM and REM. Nevertheless, we failed to detect any significant associations with POI for other ethnicities.ConclusionsOur findings indicated that FSHR rs6166 polymorphism may serve as a potential genetic biomarker of POI in Asians, but not in other ethnicities.
Highlights
Whether follicle-stimulating hormone receptor (FSHR) polymorphisms are implicated in premature ovarian insufficiency (POI) remains controversial
After exclusion of irrelevant and duplicate articles by reading titles and abstracts, 35 articles were retrieved for further evaluation
Further subgroup analyses by ethnicity revealed that rs6166 polymorphism was significantly associated with the risk of POI in Asians with both fixed-effect models (FEMs) and random-effect models (REMs)
Summary
Whether follicle-stimulating hormone receptor (FSHR) polymorphisms are implicated in premature ovarian insufficiency (POI) remains controversial. We performed this study to explore correlation between FSHR polymorphisms and POI in human beings. Premature ovarian insufficiency (POI) is currently defined as apparent deterioration of ovarian function before the age of 40 in human beings [1]. It is characterized by an elevated level of follicle-stimulating hormone (FSH), a decreased level of estrogen, oligomenorrhea or amenorrhoea as well as an increased risk of osteoporosis and multiple cardiovascular diseases [2]. According to a recent epidemiological study, the prevalence of POI is estimated to be around 1% in women younger than 40 years old [3]. Family aggregation of POI in human beings is not uncommon, and it is estimated that about 10–30% of POI patients have positive
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