Abstract
Cortex Eucommia has been used as a kidney-tonifying herbal medicine with a long history of compatibility with Fructus Psoraleae. Geniposide (GP) and geniposidic acid (GPA) are the two main chemical components in Cortex Eucommia. In the present study, the effects of Fructus Psoraleae extract (FPE) on intestinal absorption kinetics of GP and GPA in rat were investigated. Twenty four male Sprague-Dawley rats were randomly assigned into four groups which were treated with GP, GPA, GP mixed with FPE and GPA mixed with FPE, respectively, by in situ intestinal perfusion for 3 h. The samples of intestinal perfusion solutions were collected every 30 min, and analyzed by ultra high performance liquid chromatography (UPLC). The curves of time and residual quantities of GP and GPA (lnx) in the intestinal perfusion solution and the cumulative absorption rate were obtained. The results showed that FPE exhibited different effects on the intestinal absorption of GP and GPA in rat: it increased the intestinal absorption of GP (p < 0.05), while demonstrated no significant effect on the absorption of GPA.
Highlights
Cortex Eucommia, is widely used in the clinic for the treatment of kidney or muscle weakness, lumbago and fetal irritability [1]
This paper reports for the first time, the effects of Fructus Psoraleae extract (FPE) on the intestinal absorption kinetics of GP and geniposidic acid (GPA)
The results showed that both GP and GPA groups were stable in blank intestinal perfusion solution for 3 h (Table 1)
Summary
Cortex Eucommia, is widely used in the clinic for the treatment of kidney or muscle weakness, lumbago and fetal irritability [1]. GP and GPA (Figure 1) are iridoid compounds and active ingredients of Cortex Eucommia and many other Traditional Chinese Medicines [2,3,4,5]. Natural herbal medicines and their single ingredient compounds are widely used as clinical drugs, in Asia. When administered simultaneously, the herbal medicine may significantly influence the absorption pharmacokinetics of the monomer compounds, thereby affect their effectiveness and safety. Several studies [6,7] have investigated the absorption kinetics of GP or GPA, but few studies have assessed the absorption kinetics of these two compounds combined with other Traditional Chinese Medicines
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
