Abstract
The aim of this study was to evaluate both the effect of oxygen free radicals produced by ultrasonic irradiation on ubiquinone-3 incorporated into egg phosphatidylcholine vesicles and lipid peroxidation of the same vesicles. Owing to water sonolysis, degradation of polyunsaturated fatty acid residues occurred when model membranes were sonicated in the absence of ubiquinone. Under these conditions, Hepes buffer, but not formate, was able to protect against HO − damage, probably because access to the site of HO − formation is easier for the buffer. Incorporation of quinone prevented peroxidation due to HO − radicals, with a concomitant decrease of ubiquinone content. Experiments performed to evaluate the effects of varying egg phosphatidylcholine concentration on conjugated diene formation and ubiquinone stability suggest that the antioxidant effect of this compound mostly resides in its capacity to act as a ‘chain-breaker’ antioxidant.
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