Abstract
Objective The aim of this study is to identify the effectiveness of the four different watermelon frost combination medications in the treatment of oral ulcers through network meta-analysis and rank them based on their performances. Methods Five randomized controlled studies of four distinct types of a combination medication for the treatment of oral ulcers were observed in numerous databases, and a network meta-analysis was conducted to evaluate the odds ratio (OR) and sequence of the diverse treatments using Stata software (version 13.0). The underlined studies were categorized into two groups: the control group (watermelon frost alone) and the observation group (one of four watermelon frost combinations). Results The study comprised of 598 cases and the findings indicated that the pooled OR and 95% CI of oral ulcers that improved relative to watermelon frost alone were 3.26 (1.28 to 8.30) for watermelon frost and Kangfuxin fluid, 8.74 (2.94 to 26.02) for watermelon frost and erythromycin, 6.53 (1.81 to 23.50) for watermelon frost and metronidazole, and 2.62 (0.63 to 10.95) for watermelon frost and cydiodine buccal tablets. The study showed the significant efficacy of watermelon frost combination medications. In terms of clinical efficacy, the combination of watermelon frost and erythromycin was the most promising concomitant medication. It had an 86.3 surface under cumulative ranking (SUCRA). Conclusion All the studied watermelon frost combinations were effective against oral ulcers validating the use of watermelon frost for oral ulcers. The combination of watermelon frost and erythromycin is the most promising candidate among the four combinations for the treatment of oral ulcers.
Highlights
Oral ulcer is a common oral disease in clinics
E current study aimed to identify the effectiveness of four types of watermelon frost combination medications for the treatment of oral ulcers using network meta-analysis (NMA) and to rank them according to their performances. ese four schemes are most widely used to treat oral ulcers
Each database has its own set of search algorithms, which include variations on the search keywords, wildcard symbols, and Boolean operators that combine words. e searching date is from the establishment of the database to February 17, 2021. e searched words are “watermelon frost,” “combination therapy,” “Kangfuxin fluid,” “erythromycin,” “metronidazole,” “cydiodine buccal tablets,” “oral ulcer,” “mouth ulcer,” “aphthous,” “randomized controlled trials,” “efficacy,” and “drug therapy.”
Summary
Oral ulcer is a common oral disease in clinics. It is a superficial ulcer that occurs on the oral mucosa. e ulcer is mainly round or oval. e common symptom is local oral pain. is disease has the highest incidence among oral mucosal diseases and has a certain periodicity and selflimitation [1]. Improper treatment after the onset of the disease will significantly reduce the quality of life. If it is not treated timely and effectively, it is easy to involve diseases of the nervous, cardiovascular, digestive, and respiratory systems [3]. Erefore, the timely and effective clinical treatment of oral ulcer patients with scientific and reasonable treatment plans has very important clinical significance for enhancing the quality of life. E biggest advantage of network meta-analysis (NMA) is that distinct interventions for the treatment of the same disease can be indirectly compared and sorted according to the effect of a certain. E current study aimed to identify the effectiveness of four types of watermelon frost combination medications for the treatment of oral ulcers using NMA and to rank them according to their performances. Watermelon frost spray is an anti-inflammatory Chinese patent medicine. is included combinations of watermelon frost with Kangfuxin fluid, erythromycin, metronidazole, and cydiodine buccal tablets. is study may provide critical guidance for therapeutic medication selection in the treatment of oral ulcers
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