Abstract
Semisolid dosage forms are recommended for the dermal care of babies and children. If we look at the ingredients of these preparations, there are still many cases in which there are substances (occlusive agents, preservatives) that no longer meet certain requirements of the modern age, so it is timely to replace them with other substances. The aim of this work was to formulate a science-based formulation with new components that keep or improve its moisturizing properties, rheological parameters, and microbiological stability. Occlusive oils, like white petrolatum and liquid paraffin and the preservative parabens are traditional ingredients in oil in water creams, were replaced with white beeswax, sunflower oil, and phenoxyethanol, respectively. Cocoa butter, urea, and glycerol were added to improve long-lasting hydration and support the barrier function of the reformulated creams. The rheological properties of the formulations were determined. The effects of the preparations on skin hydration and on the barrier function of the skin were tested. Furthermore, microbiological stability was investigated. The result of the reformulation was an o/w cream that provided a good longer-lasting hydration effect; supported the barrier function of the baby skin without occlusion; and had adequate consistency, easy spreading, a pleasant skin feeling, proper pH, and good microbiological stability.
Highlights
The formulation of topical dosage forms like semisolids benefits from functional ingredients that improve product performance and ensure delivery
Semisolid systems can be found in both cosmetic and pharmacy practices. The ingredients of these formulations can affect the functional properties of the preparations; there is a need to select the proper excipients
There are a number of cosmetic and pharmaceutical products that are recommended for nursing infants and children, and to adults for skin care
Summary
The formulation of topical dosage forms like semisolids benefits from functional ingredients that improve product performance and ensure delivery. Semisolid systems can be found in both cosmetic and pharmacy practices. The ingredients of these formulations can affect the functional properties of the preparations; there is a need to select the proper excipients. The number of ingredients that can be used for formulations is much lower in pharmaceutical practice. There are a number of cosmetic and pharmaceutical products that are recommended for nursing infants and children, and to adults for skin care. It is very important to apply proper ingredients in baby care preparations
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