Abstract
We investigated the effect of restricted feeding (RF) on the distribution, accumulation and excretion of pentachlorobenzene (PECB) and hexachlorobenzene (HCB) in rats. PECB and HCB have similar metabolic pathways, but HCB is poorly metaboled; the half life of HCB is few months and that of PECB is a few days. Rats were fed ad libitum (AD) or given a 40% restricted diet for 29 days. On the 21st day (day 0), the rats received an equal mixture of PECB and HCB by intragastric gavage at the dose of 40mg/kg body weight. They were killed on day 1 and day 8 after the administration. The ratio of fat tissue weight to body weight in the RF rats was smaller than that in the AD rats. Large amounts of PECB and HCB were found in fat tissue, and the total amounts in the RF rats on day 1 were lower than those in the AD rats. PECB in blood of the RF rats after the administration rapidly decreased, and residual PECB in various tissues of the RF rats on day 8 was also markedly lower than that of the AD rats. In contrast, HCB in blood was slightly decreased, and the decrease in the RF rats was slower than that in the AD rats. In addition, HCB residues in various tissues of the RF rats on day 8 tended to be higher than those in the AD rats. These results indicated that the effects of RF on accumulation and on excretion of PECB and HCB are quite different.
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