Abstract
The effects of food deprivation and preliminary training treatments on choline acetylase and acetylcholine esterase activity in the dorsal hippocampus and frontal cortex of rats have been investigated. In addition, blood sugar and adrenal epinephrine levels were examined. The activity of choline acetylase and the levels of blood sugar and adrenal epinephrine were significantly altered during various stages of preliminary training but all values were comparable to pre-experimental levels before discrimination commenced. In addition, rats were injected physostigmine salicylate (0.25 mg/kg) or saline i.p. each day immediately after receiving three training trials on a food-motivated black-white task. The physostigmine injected rats were significantly better than the controls in rate learning.
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