Abstract
26 chronic epileptic patients with folic-acid deficiency due to anticonvulsant drugs have been treated with folic acid for from one to three years. In 22 patients the mental state improved. In 13 patients (50%) fit-frequency or severity was aggravated. It is concluded that folic acid partially reverses both the therapeutic (antiepileptic) and retarding effects of phenobarbitone, phenytoin, and primidone.
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