Abstract
Previous work in this laboratory has shown that the anemia which followed radiations from internal and external sources was frequently macrocytic.1,2 The macrocytosis may have been the result of damage directly to the bone marrow or indirectly through damage to the viscera, resulting in failure to form an anti-anemia factor. Folic acid, classified as a vitamin of the B complex, is reported to be similar in its action to liver extract. It has been shown to be effective therapeutically in certain of the macrocytic anemias in man.3,4 It was without effect, however, upon the macrocytic anemia that resulted from administration of Sr89.5,6 Total-body X irradiation, unlike radioactive strontium, causes damage to the viscera as well as bone marrow. It is of interest, therefore, to determine the possible therapeutic effect of folic acid on the macrocytic anemia resulting from total-body X irradiation.Male white rats were irradiated with 675 r (the approximate median lethal dose). Conditions of irradiation were: 20...
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