Effects of flupentixol and melitracen on white coat effect and blood pressure circadian rhythm in white coat hypertensive patients

Abstract

Objective To investigate the effects of flupentixol and melitracen on white coat effect and blood pressure circadian rhythm in white coat hypertensive patients. Methods A total of 120 white coat hypertensive patients were enrolled in this prospective observational study.After scoring by Hamilton anxiety scale (HAMA), 77 patients whose HAMA score> 7 points were randomly divided into two groups by a random number: 39 cases in therapy group were given flupentixol and melitracen, and 38 cases in control group were given placebo.Ambulatory blood pressure monitoring (ABPM), clinic BP (CBP), the value of white coat effect (WCE) and blood pressure circadian rhythm of two groups were observed before and after treatment. Results (1)After treatment the day dynamic blood pressure dSBP, dDBP of therapy group slightly increased in therapy group (all P 0.05); ambulatory blood pressure in control group did not change significantly (all P>0.05), the difference between the two groups was not statistically significant (all P>0.05). (2)In therapy group, office CBP decreased significantly after treatment (P 0.05). But there was significant difference between two groups (P 0.05). There is significant difference between two groups (P<0.01). (3)In therapy group, dipper circadian rhythm incidence decreased significantly after treatment (P=0.006) while no significant change is seen in control group (P=1.0). There was statistical difference between two groups (P=0.031). Conclusions Flupentixol and melitracen reduce the value of WCE in white coat hypertensive patients with anxiety and improve circadian rhythm of blood pressure.Therefore it may be a better option for this type of patients. Key words: Hypertension; Deanxit; White coat effect; Circadian rhythm of blood pressure