Abstract
Although 20 m m fluoride stimulates neutrophils to produce superoxide anion, the kinetics of production are dissimilar to those observed with other stimuli. Further, fluoride was shown to inhibit oxidation of [1- 14C] glucose, and incubation of neutrophils with fluoride did not result in significant generation of chemiluminescence or iodination of cellular material, as did other soluble stimuli. These results indicate a discordance between the effect of fluoride on superoxide generation and other metabolic parameters associated with the respiratory burst. The data suggest that fluoride might not be a useful probe for investigating the molecular basis of the respiratory burst in human neutrophils.
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